The box rear artwork and design to the Pandemic: On the Brink expansion board game. It states the contents and the extra components for the game. The red and yellow “Pandemic” titles are top-left as are the blue and yellow “On the Brink” titles. Four cards are shown in the top-right adjacent to an area describing a new game feature in shades of red and orange. A new mutation section features in the middle, in shades of purple and pink and a bio-terrorist in a red bio-hazzard suit features in the bottom-right.